Polyuria and polydipsia are not commonly seen in which endocrine disorder?

Polyuria and polydipsia are not commonly seen in which endocrine disorder?

• A. Hyperadrenocorticism
• B. Hyperparathyroidism
• C. Diabetes mellitus
• D. Diabetes insipidus

Answer: (B)

Polyuria and polydipsia happen when the kidneys lose the ability to concentrate urine or when there’s osmotic diuresis from substances like glucose. The most classic associations are diabetes mellitus, where glucosuria pulls water into the urine, and diabetes insipidus, where the kidneys can’t respond to or produce enough ADH to concentrate urine. Hyperadrenocorticism can cause PU/PD as well, due to cortisol effects on renal water handling, but that is less typical. Hyperparathyroidism leads to hypercalcemia, which can impair the kidney’s concentrating ability and cause PU/PD in some cases, but it is not commonly observed as a primary sign compared with the others. Therefore, hyperparathyroidism is the least commonly associated with PU/PD among these options.

Polyuria and polydipsia happen when the kidneys lose the ability to concentrate urine or when there’s osmotic diuresis from substances like glucose. The most classic associations are diabetes mellitus, where glucosuria pulls water into the urine, and diabetes insipidus, where the kidneys can’t respond to or produce enough ADH to concentrate urine. Hyperadrenocorticism can cause PU/PD as well, due to cortisol effects on renal water handling, but that is less typical. Hyperparathyroidism leads to hypercalcemia, which can impair the kidney’s concentrating ability and cause PU/PD in some cases, but it is not commonly observed as a primary sign compared with the others. Therefore, hyperparathyroidism is the least commonly associated with PU/PD among these options.