In a minor crossmatch, which pairing is tested?

In a minor crossmatch, which pairing is tested?

• A. T-cell production
• B. Recipient serum against donor erythrocytes
• C. Recipient erythrocytes against donor serum
• D. Recipient urine against donor erythrocytes

Answer: (C)

Crossmatching checks for antibodies that could cause a transfusion reaction by mixing donor and recipient components. In a minor crossmatch, you’re looking for antibodies in the donor’s serum that might attack the recipient’s red blood cells. So the pairing tested is recipient erythrocytes (the recipient’s RBCs) with donor serum (the donor’s antibodies). If the donor serum contains antibodies against the recipient’s RBC antigens, you’d see a reaction, indicating incompatibility for this crossmatch. This contrasts with the major crossmatch, where the recipient’s serum (containing antibodies) is tested against donor red blood cells. The other options don’t fit because T-cell production and urine aren’t part of the crossmatching process.

Crossmatching checks for antibodies that could cause a transfusion reaction by mixing donor and recipient components. In a minor crossmatch, you’re looking for antibodies in the donor’s serum that might attack the recipient’s red blood cells. So the pairing tested is recipient erythrocytes (the recipient’s RBCs) with donor serum (the donor’s antibodies). If the donor serum contains antibodies against the recipient’s RBC antigens, you’d see a reaction, indicating incompatibility for this crossmatch.

This contrasts with the major crossmatch, where the recipient’s serum (containing antibodies) is tested against donor red blood cells. The other options don’t fit because T-cell production and urine aren’t part of the crossmatching process.